I'm new to EDC so on a similar journey of discovery like the OP. I'm carrying a P365 in a Tulster Profile kydex holster. I chose that option thinking the most minimal/small sized option would be easiest to carry and conceal. I've been experimenting with my carry location and so far the most comfortable for me, walking around, sitting, driving is AIWB. The rig is short enough for me that it only offers a little pressure against my groin/aductor muscle area which is not enough to be bothersome. I've tried spending the day wearing it at 4-4:30 and it also works well for sitting and actually maybe a little more comfortable driving but it's creating a hot spot on my hip that is painful after several hours of carry.
I'm very tuned in to the idea of carry safety and the idea of where the muzzle is pointed on my striker fired handgun while it's AIWB holstered. At the risk of soliciting comments on my mental acuity, I'm initially carrying without a chambered round and practice a draw, rack, and putting rounds on target. I'm not liking that as a permanent solution so I've ordered the Wilson Combat 365 safety kit thinking I'll be more at ease with one in the pipe with the manual safety.
As I mentioned, I'm on a journey of discovery for what will work best for me. Maybe a different holster will be more comfortable at 4-4:30. It looks like a hybrid with a leather backing would spread that contact point out and maybe eliminate that hot spot on my hip? However, I've heard from a couple of sources that hybrids are the least safe holster option in that the risk of an ND is higher with the softer back. I'm not sure I understand that given that it seems the same situation would exist for an all leather holster? I'd much rather carry on my hip if I can find a comfortable solution so I'm headed down that path of a drawer full of holsters to find it. Fortunately, they aren't that expensive
