An EDC setup has to address a wide range of factors. Concealability, comfort, accessibility, durability and others. Priorities will vary greatly between people and circumstances. Body geometry and biomechanics are important personal issues.
Considering only biomechanics of draw, it is true that you'd want neutral cant at about 3:00/9:00, increasingly positive cant in the more rearward positions and increasingly negative cant in the more forward positions.
If for some (other) reason you prefer a less stable holster (high ride, single connection to belt, etc.) then adding cant probably increases instability.
What I have found (at least tentatively) is that the benefits of relatively steep cant outweigh the liabilities. Even with my 26 in stock form, ~25* of cant conceals much better than 10* or less.
With an IWB, depending on how deep you wear the holster, how long the gun is and how tall your torso is, adding cant can help keep the muzzle from poking you in the glute and interfering with access to your back pocket.
Something to consider about body geometry is that a smaller, leaner person has a more complex shape at 3:00 - 4:00 than a larger, fatter person. This is less of an issue with OWB, but an IWB rig needs to be able to work with the adjacent body form. Cutting a horizontal cross-section through someone with a 30" waist and 5% bodyfat reveals several compound radii, whereas someone with a 36" waist and 20% bodyfat will appear more circular. Same with a vertical cross-section. So cant can be used to align the gun tangent to the curves on the smaller person. I find it much more comfortable to align the gun to my hip and then adjust my wrist when drawing than vice-versa.
Steeper cant also greatly reduces the extent to which the gun's butt prints rearward when I bend forward. With the gun at 3:30, I would rather have the rear sight printing as I lean backward than the butt printing as I lean forward. One reason for this is that I can make eye contact with someone in front of me, but not someone behind me.
So at this point, for a carry rig, I'm leaning towards IWB with two widely-spaced loops, just deep enough to give a comfortable radius for middle finger at draw, ~25* cant, and positioned at 3:30 - 4:00. For matches, OWB, 3:00, neutral and a little lower.