Using a red dot that works without an adaptor plate is the way to go. The optic I have used the most while teaching with my MOS is the SCS because it mounts directly without the adaptor plate.
The issue with the MOS system is for most optics, you have to use the plates. The screws with this system don't have much in the way of thread depth for the mounting screws. You have a short set of screws that hold the adaptor plate on, the biggest possible point of failure, and then short screws holding the optic to the plate, the second possible point of failure.
The more thread depth and screw engagement, the stronger the hold. You also only have two points of failure with a direct mount instead of four. WIth an adaptor system like the MOS, you are effectively increasing your chances of a failure by %50.
I don't think the screws themselves play as big of role in the failure as the design itself, honestly. I have no doubt using the highest grade screws possible will minimize the chance of them shearing off, but I think the MOS design and tolerances play more of a role.
Any movement at all in an optic mounting system, be it direct mount or milti optic systems, creates stress as the parts move back and forth under recoil. We are talking about micro measurements between the parts, but unless the parts fit tight, there will be movement no matter how small. That movement is amplified when you introduce the forces during recoil and slide cycling.
This is why even when you get a slide direct milled, you want to use someone who knows what they are doing. If there is an excessive amount of slop, or loose tolerances between the optic and slide contact points, you can still have a greater chance of failure. I have seen poorly done milling on a direct mount, where the optic would still work it's way loose more than it should under normal use.
As I mentioned before, I use the SCS on my MOS when I do run and optic. Even thought it is direct mounted, I still keep a close eye on the screws and check them often during a class. Even thought it is directly mounted, the tolerances aren't very tight, Holosun has to leave a little room as slides are always slightly different, milling wise and Glock doesn't exactly mill their MOS slots with tight tolerances. I haven't sheared a screw off, but I have had a screws work their way loose on occasion during multi day high round count shooting.
TXPO