Sure, they both have benefits.
442 caries easier and prints less, especially if IWB. 43 is a little flatter in pocket carry.
442 might be more reliable if you don't shoot a semi-auto well. Generally the G43 is about equal in reliablity, but grip will matter more with the semi-auto. 442 will be function when shooting from inside a pocket better than the G43.
442 is easier to operate for a newbie or weaker person (but will have more recoil). Easier to open cylinder and see if loaded. Racking slide on G43 or any small semi-auto takes just a bit of technique and a tiny bit of strength and coordination. Plus if you rack the slide, then take out the mag, there could still be a round in the chamber. So with a semi-auto you have to know just a little more than with a revolver, and the sequence matters.
G43 has 6+1, 442 has 5. So 7 rounds on board is better than just 5. Plus G43 is generally quicker to reload.
Once taught proper form, the G43 will shoot easier and more accurately with less recoil for 99% of owners than the 442. But if putting in a lot more time on the 442 some of those people may be able to shoot the 442 almost as well as the G43
Power is about equal between them, with the 442 (and revolvers in general) having available a much wider range of loads. G43 typical loads are hotter and faster, but at the top end of 442 cartridges you can get heavy and stout loads.