The fact is that the single stacks do have the track record or the military, police, and civilian world wide usage and vetting that the double stacks have. They haven't been issued, used, and abused by L.E. and military. They haven't had tens of thousands of sponsored rounds ran through them in countless competitions. As far as I know, there aren't any single stack Glocks that are on record as doing the same number of rounds as the double stacks. Furthermore, logic and common sense dictates that the bigger, thicker, and more robust slide and components will beat up the gun less as well as stand up to higher round counts than the smaller, lighter, thinner single stacks.
My opinion based on what data we do have and simple logic is that the single stacks are NOT as reliable as double stacks.... It's similar to how both J-frames and L-frame/N-frames are both reliable, but of course the J-frames aren't going to stand up to a study diet of .357 as well. All that said, I think it's a moot issue as most people aren't going to run enough rounds through single stack Glocks to wear them out, and even if they do ever wear them out, parts can be replaced and Glock is likely to fix any big issues, e.i., cracked frame.
[EDIT] I do recall hearing about there being some issues with Glock's single stack 9mm mags causing a malfunction????