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Degrease the hole and the screw with acetone via a cloth and or a tip.
Apply a strip of loctite down the side of the screw. You don’t have to load up the screw with it, it will spread. Torque properly and wait 24 hours. Also, it’s a good idea to leave a dot on the screw and optic to make sure they’re not backing out over time.
 
Anything I'm planning to keep in place on a pistol slide gets hosed down with as much 262 as I can get it to hold.
I replaced the sights on my Glock and used blue on the front and that wicking green stuff (slightly less strong than blue) in the rear sight dovetail because I gave the sight just one too many file swipes when fitting it) and everything is holding together after a few thousand rounds.

Something heavy like an RDS or something, yeah I'd probably go red.
 
As said in post #2 a light coat, enough to coat the space between the threads. Wipe off the excess.
Oh and use the correct thread locker. Blue is excessive for optic plate screws. Purple, low strength is better suited.
 
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I replaced the sights on my Glock and used blue on the front and that wicking green stuff (slightly less strong than blue) in the rear sight dovetail because I gave the sight just one too many file swipes when fitting it) and everything is holding together after a few thousand rounds.

Something heavy like an RDS or something, yeah I'd probably go red.
For my Tanfo fronts, I've tried peening and using 620 on the dovetail flats, but 262 on the flats is the only 100% reliable method, with no need to peen.

For Glock fronts, I also use 262 on all surfaces. They typically loosen at 30k or so. Dawson FO in both cases. I could probably get away with 242 on the Tanfo rears, because there are 2 large screws.
 
As said in post #2 a light coat, enough to coat the space between the threads. Wipe off the excess.
Oh and use the correct thread locker. Blue is excessive for optic plate screws. Purple, low strength is better suited.
Good to know. Thanks.

I have blue laying around so that's what I've used but even that may be overkill.

I just wanted to make it clear that something stronger is definitely not a good idea for this application.
 
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