Always difficult to buy the 'right' gun for another person.
How big are your wife's hands? How much arm strength does she have? How about gripping strength? How about finger strength?
Automatics need enough gripping and arm strength to work the slide. DA automatics and revolvers take more finger strength for the trigger. Big automatics, which have lower recoil, require more arm strength. Small hands have trouble keeping a firm hold on large-gripped guns through recoil.
Just about anybody can fire just about any gun a few times. But if you buy her a gun with a trigger that's too hard, or that's too heavy, or one that she has to readjust her grip after every shot, and she'll stop shooting it after about 5-10 rounds each range trip.
I love Glocks. My wife tried to love them, too - loved the way they shot, loved the trigger, but the grips are too big and they were on the heavy side for her. So we tried a revolver. The trigger was too much, although she liked everything else about it. Eventually she settled on an S&W M&P compact. Light enough, small enough grip, and a light trigger pull not so different from a Glock.