1. You have not told us the physical disabilities, the skill sets of the user or the situation.
2. When you read #1, you haven't told us whether the user has the ability to cock a gun, operate a safety, load a revolver or load a semi auto pistol, whether the person is living in a rural single family dwelling or an urban apartment.
3. YOUR knowledge, your skill set, your experience does not go into grandma, grandson or your nephew by osmosis or blood line.
4. Yes, people will post that they want go outside of your stated limitations of a .22lr pistol. Conversely, if you don't want to provide the information in 1 and 2 above, go to a commercial gun range that rents .22lr pistols. Ask the owner which of the .22lr pistols he has purchased new seem to be reliable and long lasting in service and the most requested by rental customers.
5. Years ago, I went to a singles dinner. A woman doctor said that she wanted to buy a car and asked what she should buy. Oh the table buzzed with everyone telling her what to buy because she was a doctor, blah blah blah. I was the last to speak. I told her to take a pencil and pad of paper and go to any car dealer and sit behind the steering wheel of a car and learn what was a comfortable distance for legs to be in the car behind the driver's wheel and write that down. And then make sure that every car she tried had an adjustable seat. Then try the steering wheel and learn if it could be moved to make her comfortable and make note of the car model. And, then go through a list of what type seats were comfortable. Turned out she already bought a car. She just wanted approval. If you really want a .22lr, the guy who buys them, fixes them, and rents them every day is who you want to talk to about what you buy.