I know it wasn’t one of your choices but how about a Glock 41 MOS? Same Glock 21 mags but a slimmer slide and the most “1911-like” Glock (an oxymoron I know) there is in my opinion. I have one and it shoots like a dream.

 

My vote is for the G21 but I am a .45 aficionado. I have a G23 and really like it and the G22 is a great gun. Thinking about ammo availability down the road is a consideration. It used to be .40 would be on shelves when 9 and 45 were sold out but I don’t think manufactures will produce as much 40 going forward as previously. You will really like the characteristics of the 21. I have not shot any if the Gen 5 guns though.

 

I'm a .40 fan, especially if you're comparing a 27 to a 30 or 36. The 45 needs a longer barrel to shine. In the full size guns, it's a toss up, both will meet all your needs. 40 ammo will be a bit cheaper, may be harder to find than years past. I'm attaching a link to ballistics by the inch, if you want to compare them.

BBTI - Ballistics by the Inch :: Calibers/Cartridges

(statement of intent)

www.ballisticsbytheinch.com

 

Really can't go wrong with either. I have both. I have all 3 Gens of the 21 and IMO the Gen5 is superior in every way. I carried a Gen3 22 (my chief let me have it when we moved to Gen4) for over a decade and then a Gen4 for many years. I picked up a Gen5 22 this spring and once again, IMO the Gen5 tops the Gen3 and Gen4 that I have extensive experience with.

My ugh on the Gen5's is purely aesthetic. I can't stand the front slide serrations. Other than that the Gen5 fits great in my hand and the updated, RSA works and works well.

My answer is BOTH!

 

For HD, I alternate between my G21 and my G35. My two Glock 21's are my most accurate Glocks (between 9mm, .40S&W, .45 .acp) so the edge goes to the Gen 5 21 in my mind!

 

I love my G22.5 MOS, but after shooting the G21.5 MOS that’s the one I want badly! Best shooting 45 that I shot from Glock.
Jerry

 

I love my G22.5 MOS, but after shooting the G21.5 MOS that’s the one I want badly! Best shooting 45 that I shot from Glock.
Jerry

Good to know - a direct comparison !

 

I have both, both are very good. The G22 Gen5 shoots about like a 9mm, has the capacity advantage over the G21. Ammo wise, .40 can had for ~$300/1000rds online if you look around.
The G21.5 shoots very well too, less capacity, ammo is higher and it's a bit bigger overall. It really boils down to whether you want a .40 or a .45. Both are great options, both are very American calibers.

 

The G22 Gen 5 (by all accounts) is likely Glock's best .40 cal design to date along with being a softer shooter than past Glock .40 cal pistols

I have/had a 22.5 non MOS. The chunkier slide makes me wish I had bought a 20 or a 21.

I much prefer my 22.2 and 22RTF2 over my 22.5

Buy the 21 and eventually buy a conversion barrel for 10mm/.40 or a complete 20 slide.

 

I'd choose option 3, the Gen 5 G20 in 10mm. You can shoot tens in it AND without modification you can shoot .40's too.

 

All gen 5 glocks are awesome. Get both.

 

G22. Cheaper factory ammo, smaller grip.

 

Gen5 G22 MOS.

 

G21…… because it’s a 45.

 

Good to know - a direct comparison !

My BL dealer has a G20.5 MOS in and I might still get it since they do not think they will see the 21.5 MOS for awhile. I like the idea of shooting 40SW out of the 20.5 as well as 10mm. Plus I won’t have to keep changing my 40SW magazines base plate to a different color. LOL

 

*I now think the real comparison should have been between the G21.5 MOS vs. the G20.5 MOS as both feature multi- conversion barrel calibers .

 

Getting barrels and other pieces to convert a gun into other calibers is a great way to throw away a lot of money.

 

I would say G20.5 MOS as mentioned above for the same reasons.

 

I have a gen-3 21sf with a moa cut slide and a gen-5 20, the 21 is a night stand gun and the 20 is my out in the woods gun. now that I have a heavy weight recoil spring in the 20 it would be my choice for just one pistol.

 

The G21 is more accurate than a G22 or the G20, but the G22 is more suited to gun games, and the G20 is more suited to hunting.

 

Best millimeter or G22.

 

G20 Gen5 MOS gives you the best of both worlds.