Yep. Even experienced and skilled med/lge revolver shooters often find acclimating to the smaller 5-shot snubs a new task to learn to master. Even more so if you're talking about the Airweights or Airlites (PD/SC/Ti snubs). The very attributes that make them so attractive and handy for lawful CCW also tends to make them harder to control and shoot accurately.
The same thing can be said for the diminutive pistols.
Several years after I'd transitioned from revolvers to many assorted pistols, I bought my first Airweight (642-1). I'd only been carrying and shooting all-steel 5-shot snubs (36, 649, CA Bulldogs, SP101), so the aluminum-framed Airweight was a new experience. Even as a longtime Magnum revolver owner/shooter and firearms instructor, I needed to refresh my DA revolvers skills to deal with the lighter DAO snub. It took me 2-3 cases of +P loads (158gr LSWCHP in those days), mixed with a case of some 110gr +P+ fired in an early 640 marked for +P+ ammo), to feel I was really acclimating to the demands of the lighter gun. Once I was able to run the little Airweight hard and fast I felt I'd finally found my groove and was able to do demanding qual scenarios and fast shot strings and drills as accurately as I desired.
Lesson learned, though. Even though I was still buying and using a lot of small compact and subcompact pistols during and after that time, I made sure I always included range time for drills, practice and quals with the Airweight. Then, I started buying more of them.

(Another 642-1, a pair of M&P 340's and a nifty 37-2DAO.) I still include my all-steel snubs for occasional range time, but I spend the bulk of my range work drills & quals (retirement & LEOSA) running one or another of the lightweight snubs, to maintain things.
I've watched my fair share of shooters (as an instructor) bring their latest small, lightweight pistols to range sessions and experience discomfort and problems shooting them. Sometimes the larger and heavier pistols are the better choice for folks who can't easily, controllably and accurately run the ever increasingly smaller models (and heavier recoiling calibers) of pistols. It can quickly reach a point of diminishing returns.