[Mountain10mm]

It's an interesting question because the slide is moving, but that being said, Smith and Wesson revolvers use a screw mount system for their scopes and rings...and Smith makes some BIG revolvers. Most extremely large bore and powerful hunting rifles also use a screw mounted ring, drilled and tapped into the receiver. Another plus is that the mass of the red-dot (assuming something like a Burris Fastfire II) is relatively small compareable to even a small scope. If you could get it to work and not be position overly high on the slide, I think the scews would more-than carry the load.