From my experience, the 5.7 was extremely popular when it first come out.
The reason being is, at that time the ammunition penetrated bullet proof vest.
Shortly after, this ammunition was banned in the USA.
FN 5.7 cost is about $1200.00 today.
If you research the 22 mag vs 5.7 velocities they are very close. Around 2000 fps.
Ammo costs is also a consideration.
5.7 ammo is about $20- 25 per box of 50 and 22 mag ammo is about $10 to 15 per hundred.
IMO, the lack of demand for a Glock 5.7 would not support Glocks manufacturing costs.
The 5.7 ammo is too expensive for target shooting unless you reload. Plus, 9mm, 40, 45 pistol calibers are most commonly used for self defense.
In closing , remember the 5.7 is often referred to as a glorified 22 caliber.
22 LR CCI high power cartridge is advertised at 1600 fps.
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Sorry to dig up an old thread but I found it in a Google search.
There's so much misinformation in this comment I felt I had to reply.
For starters, the ammo that can easily penetrate Level 3A armor isn't illegal at all. FN restricted their SS190 and SS198LF rounds to military/LE but it's still easily found online for civilian sale. Not only that but there are numerous other options available from both Elite Ammunition and Vanguard as well as even the new Speer Gold Dot that will penetrate 3A out of a Five-seveN or Ruger 57 and still leave a nasty wound channel in ballistics gel (there and videos on YouTube by Buffman proving it).
It's time to get over the "it's just a glorified 22 mag" thing. First of all, 22 mag is rimfire, nobody in their right mind would carry a rimfire cartridge for SD. Secondly, you're taking 22 Mag & 22lr advertised velocities from rifle barrels and comparing it to ~5" pistol barrels for the 5.7x28. The discontinued Elite Ammo S4M round is clocked between 2500-2600 fps, weather depending, out of a Five-seveN and there are multiple other current production options well over 2000fps out of a 5" barrel.
Most of the wounding from the 5.7x28 is based upon its fast, light bullet that tumbles after a few inches creating massive destruction considering the size of the projectile. Most rounds will do this with or without going through a vest. Obviously the SS197 and American Eagle rounds are range ammo but just about every other round out there does what the 5.7 was designed to do. Penetrate armor and cause a mess on the other side.
With the growing number of manufacturers bringing out their own 5.7x28 guns in the last two years (Ruger 57, Diamondback DBX57 and one from KelTec) i think it'll only make the round become more popular and cheaper in the long run. Not to mention the fact that it was standardized by NATO just a few weeks ago. Google how many NATO Standardized rounds there are, that alone might say something for the 5.7x28. As much as I love my Five-seveN, if Glock developed a gun clambered in 5.7x28 I'd sell my FN and buy two of the Glocks right away.