I don't have any problems using my suppressed handguns as intended. Where are you having problems?
I'm not saying don't get one, they're cool. And I would not call them problems, merely differences: the extended length, added weight, changed POI, impeding the standard sight picture, potentially less reliability of the gun, and being one more thing needing to be disassembled and cleaned (I actually like that part). They just reduce the practicality of what any handgun was originally designed for and produced from the factory. Albeit suppressors do reduce noise, and they look cool too. So, there is a special, fun place for them.
Here's where I get on my soap box; I used to keep a suppressor on my nightstand handgun, but the more I thought about it, I no longer do that. Why? For one, if a gun gets stolen, you have to report that, and probably never see it again etc. You'll have a police report number and that will be the end of that. But if a suppressor also gets stolen, now you have a lost NFA item and I'm sure the reporting and legal problems could/would intensify. For instance, if you lent your NFA item to someone who was not the owner or on your trust, and you were not with them, wouldn't you, the owner face consequences? Leaving an NFA item out and unlocked, even though it is in your home, would be more of a debacle to deal with, I would think. But I mostly don't keep a suppressor on my nightstand gun anymore because if I get into a situation where I need to use my gun, I WANT my neighbors and especially my family members in the house to hear it. THEY could be the ones who are able to make a 911 call if I cannot. I WANT them all to be potential witnesses by hearing what time they heard gun shots; how many shots did they hear; the more witnesses the better. And I would want to make them all aware that something is going down so they could prepare themselves for whatever it is. A suppressor could possibly hinder all that. I would love to save my ears, believe me, and I would not like the muted hearing after discharging a firearm inside, but I think the alarming factor to others of a gun firing is worth it. If I still lived out in the farmhouse that would be one thing. Being quieter with a suppressor would definitely be nice and desired. But I live in town nowadays, have a family and neighbors and choose this way again for now. YMMV.