Aceman, depends on what you want to accomplish really. As far as basic needs you seem to have it covered. I would want a .22 handgun, and if just one, more of a full size rather than the small semi-autos like the Ruger SR22 that are popular. I would go Ruger Mk whatever, Browning Buckmark, or Ruger Single Six in revolver. The Single Six is available with .22 WMR extra cylinder. Or like others have said, an older S&W K frame .22. I like the little SR22 and would like to own one, but these others will show you what a .22 is capable of in accuracy and versatility. I somewhat prefer a .44 over a .357, but since you already have the .357 lever, I would go with .357. Ruger GP100 or older Smith. Ruger Blackhawk if you think a single action is something you would like. While I like 10mm, and performance is similar, it would be a second choice or something to get after I had the revolver. I think everyone should at least try a good 1911 in .45 ACP; in my mind your experience is incomplete without it. It is not a necessity though, and you have any needs it would meet covered. While I want a PCC, it doesn't fill a need you don't have met. If I were to say, "Go get these", I would say Ruger Stainless Single Six with 5.5 inch barrel and extra cylinder, and one of the many variations of the Ruger GP100 with at least a 4 inch barrel. The likelihood of you telling me I gave you bad advice would be almost nil.