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I would have to say the .45 ACP or the .45 Colt. The .357, I think, would blow a very fast hole through somebody unless it struck bone. I think the 9MM is quite sufficient with SD ammunition. With FMJ, I'm not so sure. A friend did shoot an enemy soldier during the Gulf War and he went right down and died, but my friend said he fired a burst of three at about 20 feet from his Beretta.