As long as the add'l recoil doesn't affect your shooting, sure why not. I can shoot a full house 44mag in a 4" revolver pretty well, but is it worth the pounding & add'l gun wt? Maybe for a bear gun but not for a ccw. Still, I can shoot & hit faster & better with a subcompact 9mm +p, Easier to carry too. So run the drills, the timer & target never lie. Just be realistic & honest with yourself. At contact we all can land hits pretty fast, regardless of caliber, even that 4" 44mag. The diff will be when you move to just 21ft, and things really slow down for the lesser skilled shooters past that.