This new coronavirus epidemic is starting to heat up
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The Friday update for Kansas is out and it brings another addition to it. We added another 1,208 new cases for a total of 286,102. 8,887 have been in hospitals and 6,057 have been discharged. Another 61 deaths brings the grim toll to 4,346.
1,217,589 people have been tested, 2,346,453 PCR tested performed and 527,458 Antigen tests performed also. The monthly testing rate per 100K is 1,124. The monthly Percent positive is 5.4&, down .3%.
110 hospitals in this update. 950 ICU beds with 537 in all uses and 87 in use for covid patients. 43% of ICU beds are available. 1,009 ventilators with 156 in all uses and 42 in use for covid patients. 85% of ventilators are available.
Another sit reports that Kansas has administered 331,022 doses of vaccine. 166,932 are single doses and 82,045 have had 2 doses.
The state reports 192 cases in my county and the health department reports 181 cases, 8 active and 6 deaths.
1,217,589 people have been tested, 2,346,453 PCR tested performed and 527,458 Antigen tests performed also. The monthly testing rate per 100K is 1,124. The monthly Percent positive is 5.4&, down .3%.
110 hospitals in this update. 950 ICU beds with 537 in all uses and 87 in use for covid patients. 43% of ICU beds are available. 1,009 ventilators with 156 in all uses and 42 in use for covid patients. 85% of ventilators are available.
Another sit reports that Kansas has administered 331,022 doses of vaccine. 166,932 are single doses and 82,045 have had 2 doses.
The state reports 192 cases in my county and the health department reports 181 cases, 8 active and 6 deaths.
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The following illustrates the problem with recombination. Recombination could allow the spike protein from SARS CoV 2 to wind up in Coronaviruses that currently only infect animals.
#1
bioRxiv - Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
Today, 07:24 AM
Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
Stephen A. Goldstein, View ORCID ProfileJoe Brown, Brent S. Pedersen, Aaron R. Quinlan, View ORCID ProfileNels C. Elde
doi: Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract
The ongoing SARS-CoV-2 pandemic is the third zoonotic coronavirus identified in the last twenty years. Previously, four other known coronaviruses moved from animal reservoirs into humans and now cause primarily mild-to-moderate respiratory disease. The emergence of these viruses likely involved a period of intense transmission before becoming endemic, highlighting the recurrent threat to human health posed by animal coronaviruses. Enzootic and epizootic coronaviruses of diverse lineages pose a significant threat to livestock, as most recently observed for virulent strains of porcine epidemic diarrhea virus (PEDV) and swine acute diarrhea-associated coronavirus (SADS-CoV). Unique to RNA viruses, coronaviruses encode a proofreading exonuclease (ExoN) that lowers point mutation rates to increase the viability of large RNA virus genomes, which comes with the cost of limiting virus adaptation via point mutation. This limitation can be overcome by high rates of recombination that facilitate rapid increases in genetic diversification. To compare dynamics of recombination between related sequences, we developed an open-source computational workflow (IDPlot) to measure nucleotide identity, locate recombination breakpoints, and infer phylogenetic relationships. We analyzed recombination dynamics among three groups of coronaviruses with impacts on livestock or human health: SARSr-CoV, Betacoronavirus-1, and SADSr-CoV.
We found that all three groups undergo recombination with highly diverged viruses, disrupting phylogenetic relationships and revealing contributions of unknown coronavirus lineages to the genetic diversity of established groups. Dynamic patterns of recombination impact inferences of relatedness between diverse coronaviruses and expand the genetic pool that may contribute to future zoonotic events. These results illustrate the limitations of current sampling approaches for anticipating zoonotic threats to human and animal health.
Competing Interest Statement
The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1...02.03.429646v1
#1
bioRxiv - Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
Today, 07:24 AM
Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
Stephen A. Goldstein, View ORCID ProfileJoe Brown, Brent S. Pedersen, Aaron R. Quinlan, View ORCID ProfileNels C. Elde
doi: Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens
This article is a preprint and has not been certified by peer review [what does this mean?].
Abstract
The ongoing SARS-CoV-2 pandemic is the third zoonotic coronavirus identified in the last twenty years. Previously, four other known coronaviruses moved from animal reservoirs into humans and now cause primarily mild-to-moderate respiratory disease. The emergence of these viruses likely involved a period of intense transmission before becoming endemic, highlighting the recurrent threat to human health posed by animal coronaviruses. Enzootic and epizootic coronaviruses of diverse lineages pose a significant threat to livestock, as most recently observed for virulent strains of porcine epidemic diarrhea virus (PEDV) and swine acute diarrhea-associated coronavirus (SADS-CoV). Unique to RNA viruses, coronaviruses encode a proofreading exonuclease (ExoN) that lowers point mutation rates to increase the viability of large RNA virus genomes, which comes with the cost of limiting virus adaptation via point mutation. This limitation can be overcome by high rates of recombination that facilitate rapid increases in genetic diversification. To compare dynamics of recombination between related sequences, we developed an open-source computational workflow (IDPlot) to measure nucleotide identity, locate recombination breakpoints, and infer phylogenetic relationships. We analyzed recombination dynamics among three groups of coronaviruses with impacts on livestock or human health: SARSr-CoV, Betacoronavirus-1, and SADSr-CoV.
We found that all three groups undergo recombination with highly diverged viruses, disrupting phylogenetic relationships and revealing contributions of unknown coronavirus lineages to the genetic diversity of established groups. Dynamic patterns of recombination impact inferences of relatedness between diverse coronaviruses and expand the genetic pool that may contribute to future zoonotic events. These results illustrate the limitations of current sampling approaches for anticipating zoonotic threats to human and animal health.
Competing Interest Statement
The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1...02.03.429646v1
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Just what we need.
Thanks china and who.
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And apparently we're also assuming it was natural and not a lab virus.
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Thanks for posting. It's interesting that he was personally so low given that he had been taking increased dosage.
One thing that I thought about during this video was his acceptance of what seemed to be "dollar store" quality of vitamin supplements. He has referenced generic type tablets and assumed they deliver as promised. In the states, that market seems to be largely unregulated.
Could his relative deficiency be from poor quality supplements? I tend to buy at least middle grade vitamins. Is there a difference? I don't truly know. After watching this video, I may up my "winter dose" of vitamin D from 2000IU to 3000. I don't think it'll hurt anything and may help until the southern sun comes back in force.
"You will receive an email and text from Carbon Health with information about your second appointment 3-7 days before your second dose appointment. Most appointments will be scheduled approximately 28 days after your 1st appointment and all will be scheduled within the CDC recommended time frame".
The LA information changes daily. Translated - we changed our minds at Carbon Health. You will be told at the last, moment, if at all, my be 6 weeks after we first indicated that you might receive the second shot.
The LA information changes daily. Translated - we changed our minds at Carbon Health. You will be told at the last, moment, if at all, my be 6 weeks after we first indicated that you might receive the second shot.
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Re-infection:
www.france24.com
Covid-19: Patient in France critical after reinfection with S.African variant
Doctors in France are treating a critically ill patient infected with the South African coronavirus variant, four months after he recovered from Covid-19, in what study authors said was the first cas…
I had heard a little about this not long ago, a doctor who "stole" 10 doses of the vaccine. Of course, there are multiple sides to the story... this is from the doctor's side:
"Ten doses of the Covid-19 vaccine would expire within hours, so a Houston doctor gave it to people with medical conditions, including his wife. What followed was “the lowest moment in my life,” Dr. Hasan Gokal said. "
The Vaccine Had to Be Used. He Used It. He Was Fired.
"Ten doses of the Covid-19 vaccine would expire within hours, so a Houston doctor gave it to people with medical conditions, including his wife. What followed was “the lowest moment in my life,” Dr. Hasan Gokal said. "
The Vaccine Had to Be Used. He Used It. He Was Fired.
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The weekend update is out for Kansas. Another 1,348 cases for a total of 287,450. 8,923 have been admitted into hospitals and 6,087 have been discharged. Deaths have been trending down over the last several days. Another 42 deaths brings that grim total to 4,406.
1,224,2322 people have been tested, 2,364,665 PCR tests administered and 534,602 antigen tests administered also. 936,782 testing negative. The monthly testing rate per 100k is 1,326. The monthly percent positive is 5.4%, unchanged from the last update.
54 hospitals in this update. 753 ICU beds with 393 in all uses and 77 in use for covid patients. 48% of UCU beds are available. 851 ventilatoers with 161 in all uses and 38 in use for covid patients. 81% of ventilators are available.
The state reports 192 cases with the county health department not reporting because of the holiday. Their last update was 181 cases, 8 active and 6 deaths.
A separate site reports that Kansas has administered 365,180 doses. 181,676 first doses and 91,752 2nd round doses.
1,224,2322 people have been tested, 2,364,665 PCR tests administered and 534,602 antigen tests administered also. 936,782 testing negative. The monthly testing rate per 100k is 1,326. The monthly percent positive is 5.4%, unchanged from the last update.
54 hospitals in this update. 753 ICU beds with 393 in all uses and 77 in use for covid patients. 48% of UCU beds are available. 851 ventilatoers with 161 in all uses and 38 in use for covid patients. 81% of ventilators are available.
The state reports 192 cases with the county health department not reporting because of the holiday. Their last update was 181 cases, 8 active and 6 deaths.
A separate site reports that Kansas has administered 365,180 doses. 181,676 first doses and 91,752 2nd round doses.
Today, February 15, 2021, the Carbon Health, an administrator for LA County has changed the wording again on 2nd appointments. There is no longer language about auto appointments or giving second appointments to each person within 10 days after January 31, 2021. Now the language is conforming to what I said it would be weeks ago. You are guaranteed a second dose within 6 weeks of your first dose. And, that language will change again. It finally say, something along the lines of "{it is not the fault of Carbon Health that you never got a second dose, blame someone else".
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Recombination has finally reared its ugly head. I was afraid this was going to happen.
#1
Exclusive: Two variants have merged into heavily mutated coronavirus
Today, 02:13 PM
Source: https://www.newscientist.com/article...d-coronavirus/
Exclusive: Two variants have merged into heavily mutated coronavirus
The UK and California variants of coronavirus appear to have combined into a heavily mutated hybrid, sparking concern that we may be entering a new phase of the covid-19 pandemic
Health 16 February 2021
By Graham Lawton
Two variants of the SARS-CoV-2 coronavirus that causes covid-19 have combined their genomes to form a heavily mutated hybrid version of the virus. The “recombination” event was discovered in a virus sample in California, provoking warnings that we may be poised to enter a new phase of the pandemic.
The hybrid virus is the result of recombination of the highly transmissible B.1.1.7 variant discovered in the UK and the B.1.429 variant that originated in California and which may be responsible for a recent wave of cases in Los Angeles because it carries a mutation making it resistant to some antibodies.
The recombinant was discovered by Bette Korber at the Los Alamos National Laboratory in New Mexico, who told a meeting organised by the New York Academy of Sciences on 2 February that she had seen “pretty clear” evidence of it in her database of US viral genomes.
If confirmed, the recombinant would be the first to be detected in this pandemic. In December and January, two research groups independently reported that they hadn’t seen any evidence of recombination, even though it has long been expected as it is common in coronaviruses.
Unlike regular mutation, where changes accumulate one at a time, which is how variants such as B.1.1.7 arose, recombination can bring together multiple mutations in one go. Most of the time, these don’t confer any advantage to the virus, but occasionally they do.
Recombination can be of major evolutionary importance, according to François Balloux at University College London. It is considered by many to be how SARS-CoV-2 originated.
Recombination could lead to the emergence of new and even more dangerous variants, although it isn’t yet clear how much of a threat this first recombination event might pose.
Korber has only seen a single recombinant genome among thousands of sequences and it isn’t clear whether the virus is being transmitted from person to person or is just a one-off...
#1
Exclusive: Two variants have merged into heavily mutated coronavirus
Today, 02:13 PM
Source: https://www.newscientist.com/article...d-coronavirus/
Exclusive: Two variants have merged into heavily mutated coronavirus
The UK and California variants of coronavirus appear to have combined into a heavily mutated hybrid, sparking concern that we may be entering a new phase of the covid-19 pandemic
Health 16 February 2021
By Graham Lawton
Two variants of the SARS-CoV-2 coronavirus that causes covid-19 have combined their genomes to form a heavily mutated hybrid version of the virus. The “recombination” event was discovered in a virus sample in California, provoking warnings that we may be poised to enter a new phase of the pandemic.
The hybrid virus is the result of recombination of the highly transmissible B.1.1.7 variant discovered in the UK and the B.1.429 variant that originated in California and which may be responsible for a recent wave of cases in Los Angeles because it carries a mutation making it resistant to some antibodies.
The recombinant was discovered by Bette Korber at the Los Alamos National Laboratory in New Mexico, who told a meeting organised by the New York Academy of Sciences on 2 February that she had seen “pretty clear” evidence of it in her database of US viral genomes.
If confirmed, the recombinant would be the first to be detected in this pandemic. In December and January, two research groups independently reported that they hadn’t seen any evidence of recombination, even though it has long been expected as it is common in coronaviruses.
Unlike regular mutation, where changes accumulate one at a time, which is how variants such as B.1.1.7 arose, recombination can bring together multiple mutations in one go. Most of the time, these don’t confer any advantage to the virus, but occasionally they do.
Recombination can be of major evolutionary importance, according to François Balloux at University College London. It is considered by many to be how SARS-CoV-2 originated.
Recombination could lead to the emergence of new and even more dangerous variants, although it isn’t yet clear how much of a threat this first recombination event might pose.
Korber has only seen a single recombinant genome among thousands of sequences and it isn’t clear whether the virus is being transmitted from person to person or is just a one-off...
Los Angeles:
I looked and this is what I found posted today:"
If you received your first dose under the old system, someone from Carbon Health should be reaching out to schedule your second dose (this is the way it's supposed to be working, but we are hearing that's not the case for many of you)."
Gee whiz! I thought that the governmental entity was never going to wake up. So, the story is, just show up either 21 or 28 days after your first shot through the government and hope for the best.
Our youthful and energetic Mayor has had his shots.
I looked and this is what I found posted today:"
If you received your first dose under the old system, someone from Carbon Health should be reaching out to schedule your second dose (this is the way it's supposed to be working, but we are hearing that's not the case for many of you)."
Gee whiz! I thought that the governmental entity was never going to wake up. So, the story is, just show up either 21 or 28 days after your first shot through the government and hope for the best.
Our youthful and energetic Mayor has had his shots.
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Damn. It's been strangely quiet on the COVID front these past few weeks, relatively speaking. And now this. Almost as if the sky is ready to open up. Again.
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