What are you IMMEDIATELY grabbing. I don't mean what you would have if the scenario dictated, but I'm talking about RIGHT now. You have seconds to react. What is within reach to fend off a knife wielding attacker? I have a S&W 642-2 loaded with Speer Gold Dot 125 +P and a speed loader of Fiocchi Xtrema, sitting right next to my keyboard on the desk, and several pistols in the safe next to it and that's about it.