My wife uses a Ruger 10/22 for her HD gun. She has CCI Mini-mags for her round of choice. I am the primary HD weapon. I come armed with a G21sf, Remmy 870 tactical, and a G34 backup. I also come equipped with a lifetime of martial arts training. Something that my wife also comes with. I have seen what little 22lr rounds can do to someone. They can take down some crazy animals down and I am sure they would work OK for HD, but they are only used in our house as a backup. 50 rounds of lr ammo can still make a BG have a super bad day.