Well, I took the Python (2020) back to the range this morning and ran 150 rounds of my reloads through it. Everything went fine until about 125 rounds or so, when I got a "misfire." Upon checking I found the cartridge had fired, but nothing had happened. A classic cylinder didn't advance situation. I tried a couple of dry fired and everything worked, so I figured I had done something goofy and went back to shooting. A couple of cylinders later...same thing. This time I did some more investigating and found the two screws on the left side were loose. The one over the trigger was so loose the sideplate wasn't pulled down flush. I got out the screwdriver (always in my range bag) and tightened both both up and went back to shooting. No more issues for the remaining 25 rounds, and I don't know how many dry fires since. Total rounds to date, 500. Purple locktite is on the shopping list. We all like pictures. The screws in question are on the left side, just ahead of the trigger, and under the grip. Since the sideplate serves to hold all those little parts in the right place if they get loose all the internals can get all cattywampus and out of wack.