Yes, to a point. Unless you can gaurantee head shots at any reasonable attack distance, you and the tarhet moving, caliber does matter, bullets do matter. Reagan barely slowed down with a 22lr in his chest. Yep he would certainly have died but he survived for quite awhile in discomfort until the hospital. Imagine an angry, adrenaline filled attacker? He'll take that body shot or two or three & beat you to death with your own gun before he dies.