I've been loading for a while now handgun and rifle. I have worked up loads for my rifles with pretty good results. For my handguns (44,357 and 40) I pretty much pick powders that aren't too dirty and that cycle the action in my guns. For rifle I load up in .3gr incriments to find my sweet spot for accuracy. Are handguns the same? Do they have a specific sweet spot with a bullet and powder combo? I have settled on 22.5 H110 for my 44 eagle, cycles the action fine and is accurate if I do my part. I use 231,Bullseye,AA#5,and power pistol for my 40. All my loads are for paper punchin and don't really load anything real hot. About 5 gains Bullseye for a 180jhp type load. If I did my part would I see a difference between 4.8, 5, 5.2 etc? Hope this makes sense to you guys? Thanks much.