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Why and what way does the 41 have a slimmer profile than the 21?

Is the 21 stronger in some way than the 41, and if so, are there differences in the top end Buffalo Bore type .45ACP ammo that they can handle?
The 41 slide is thinner like the Glock 30S. It is thinner and lighter to make it easier to carry and handle. Probably soaks up less recoil though but shouldn't affect durability.

The 21 has the same slide thickness as the 20 which is pretty beefy.
 
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