for me the biggest point to address is if the particular firearm fit me.
I.E...
had a Gen 3 Glock 21, I felt the frame was too big as when firing hotter round I'd have to adjust my grip after a couple rounds, couldn't lock down on it with my grip.
had a Gen 3 Glock 26, couldn't get used to the pinky under the mag so I got higher capacity mags (19 & 17 mags) and added an X Grip, got ring finger pinch when doing rapid mag changes so I switched to a Gen 4 Glock 23.
I have a Glock 43X, seemed small, I added a Hogue beavertail grip sleeve with finger grooves which causes me to feel I have the best grip, hot rounds and mag dumps are no issue.
caliber is important, capacity is important, concealment is important but fit is key, whether you find a sidearm that just fits your hand or you are able to use a grip frame enhancement (read grip sleeve) to fit your hand.