My FNP-45 USG had loads of failure to feed issues with various hollow-point cartridges (Gold Dot and HSTs). It took two trips back to the FNH factory and was ultimately replaced with a new pistol by FNH. I do not consider the design to be reliable enough for serious consideration.
I have a Glock 21 which has functioned perfectly with every single type of round I've placed in it, has less perceived recoil despite a lower weight, sacrifices only one round in the magazine when comparing flush fitting magazines (the 15 round FNP-45 magazine has an extended floor plate), and it costs less to boot. I had considered the HK45 but I couldn't figure out any reason why it cost nearly $1,000 and only held 10 rounds. The double action trigger is among the worst in its class IMO.