If you don't hit a vital organ or structure, you will not stop a fight. Simple as that. I don't care if it's with a .45 ACP that expanded to 3 FEET, if you miss vitals, you aren't winning. Handguns (9mm, .40, .45) don't do a thing but poke holes, JHP or not, and a .357" hole in the Aorta is just as effective as a .45" hole. I would prefer to use something designed to penetrate, and get to what it needs to put a hole in, than use something designed to STOP MOVING inside the body. So if I didn't have to worry about every round going passing through a bad guy, and potentially wounding someone innocent, I would carry FMJ and be just as content, if not more.