While I've never owned one myself, for some 5+ years I shared an office with a guy whose wife raised, bred and sold tarantulas for a living.
They are absolutely amazing to watch and I find them rather fascinating. I learned a lot from Jon and his wife. At their home they had some 50+ adults including one from the local zoo that was as large as a salad plate. She ate small rodents.
And he's right, they don't like to be dropped. They kinda "break" when you do that.
My brother had one for a while. I forget the actual maintenance required. I can ask him for ya and get back to ya. If you are interested in handling it, I would recommend that you start young. If you don't handle it often enough, it won't like being held. I think my bro's brushed a fang against me when I was holding it and needless to say I never held it again. Neither did my brother and it ended up being extremely shy.