How many have done this? How successful have you been? I was looking at some of the stats and ballistics on the various .22 and .17 rimfires. It seems to me that the .17 M2 is very much a niche cartridge. Costs nearly as much as a .17HMR, has almost as flat a trajectory but only a fraction of the energy, especially past 50 yards. It doesn't even compare favorably against .22lr, especially the hotter CCI ammo. It seems like if you can judge distances well and you know the zero for your scope at 50 and 100 yards you are better off with the long rifle. I think it has a lot going for it against small game at 75 yards or less, especially if you are trying to make a quick head shot. Seems to be a poor rimfire choice for coyotes overall, though. The .17HMR is an interesting choice. In bulk you can pick it up for about $90 for a 500 round brick. Compared to .22lr that's fairly pricey, but you really wouldn't use this stuff as a plinker anyway. The trajectory is very flat and at ranges below 50 yards this stuff seems to be devastating. On the other hand, it's kind of a light round with little penetration, especially at 100 yardfs or more, thus negating some of the benefits of a flat trajectory. The .22lr is dirt cheap and has a lot of variety in terms of bullet weight and performance. The trajectory isn't anywhere near a .17 HMR though, but if a person knows how to adjust the scope and/or adjust his aim appropriately it should still be plenty accurate in capable hands. The new CCI "velocitor" seems to be specifically made for coyotes, as it has about the same energy at 100 yards as a .17 HMR but about 2.3 times the weight.