IMHO, If you are shooting 45Super out of a standard Glock21 barrel, you are pushing your luck. I don't know about the LWD barrel. For shooting 45Super it is all about support. If you look at the photo I posted above, I was shooting the 45Super in an unsupported barrel and I got bulge. IMHO, If you are going to push the 45Super as hard as possible, you need a compensator. I believe Buffalo Bore is loading the 45Super so you don't have to find a local person who may or may not be competent to load your ammo, but....... IMHO, 1. If you want to shoot hot and heavy in a Glock. 2. If you don't reload 3. If you don't want to beat your gun into the ground 4. If you don't want a comp. Get a G20. Most people are happy with the 10mm. The G21 with special barrel with comp where you have spent a good bit of time slowly working up loads selecting the correct bullet is the most powerful Glock out there.