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Deer aren't tougher. Where they excel is in their instincts versus the humans ability to reason. From the data I've seen, most gunfights are stopped when one side stops fighting, not when one side is incapable of fighting. Deer don't play by those rules. They run like hell or fight. The vast majority of the time, they run like hell, as you stated. Likely, to die elsewhere.Deer are tougher than people. A deer can take a 12ga slug through the chest and still run away to die. A human shot side to side through both lungs with a slug "ain't goin' nowhere". Due to natural flight instinct, adrenaline, and quadriped balance and agility, a deer is just harder to drop.
When deer hunting, one shot is preferred as the rest will be after a fleeing target and any hits will further damage the meat.If the .45 ACP is so good for a 250-lb felon, why wouldn't it be good for a 200-lb deer at 50 yards or closer?
When defending against a "250 pound felon", sending more than a few rounds is more feasible and your concern is survival, not salvage.