I'm pretty sure I will get some grief for this but I keep my 21SF in a small safe next to my bed with the magazines loaded but not in the gun. I've always felt most comfortable and safest doing it this way. Thank God nothing has happened to me or my family for me to test the time it takes to load the pistol and be totally prepared for a confrontation. Just curious, what is the set-up for your bedside gun ?? I've heard some people sleep with a loaded gun underneath their pillow...yikes !!