It depends mostly on the hardness of the steel.
And what you call "large caliber."
If it is mild steel, a .30-06 will either blow through or crater it so deep that splashback will be severe. Maybe not dangerous at 100 yards, but maybe so.
If it is hard steel, say AR 500, it will do fine.
Or if your large caliber is a .45-70 with lead bullets at black powder speed, that will do.
I have a few facts and a lot of opinions.