The Glock 22 RTF2 is a Glock with a little flare (surprised it wasn't in Office Space). It's typically reliable, lightweight, soft shooting, more accurate than 99% of the people that shoot it, and extremely simple in design and function. The thing that sets it apart from it's ugly counterparts is the gill serrations on the slide and the more aggressive texturing on the frame...
-Reliable (0 malfunctions of any kind; with and without tac light attached)
-Excellent traction from the grip texturing
-Easy to maintain
-TONS of aftermarket support
-Only 23oz -Accepts 15 and 22 round factory magazines
-Glock's customer service is second to none
-Cheap replacement parts, should you ever need them
-Low Bore Axis resulting in a relatively soft shooting gun
-Easily modified to fit the shooters' preferences
-Requires very little cleaning/lubrication to run reliably
-I think the gills add a little more positive grip when cycling the action even though some think they're backwards
-It's a versatile platform. 357sig and 9mm conversions are very simple.
-They're becoming harder and harder to find-I'm not a fan of the factory plastic sights
-Can irritate some peoples' skin if they carry it against the skin
Here's a video with some shooting from the 12m line, a table top review and discussion, a size comparison with other Glocks and a P229, and a chronograph test with some popular defensive loads.
Final thoughts: The RTF2 frame Glocks are my personal favorite choice for every type of use (HD, range, competition, ect...) besides carry. For people that make a living with a gun in their hands I'm not sure there's a better choice out there.
Winchester Ranger 135gr JHP: 1180fps, 417 ft/lbs energy
Speer Gold Dot 180gr JHP: 1014fps, 411 ft/lbs energy