[fastbolt]

I think that some folks might give the following possibility some serious consideration ...

Namely, that they may have chosen some handgun/caliber/ammunition combination to carry as a dedicated lawful defensive carry weapon, but may have been doing so with a misplaced sense of confidence of the "effectiveness" of the combination.

It's a handgun. Even shotguns and rifles aren't guaranteed to provide "one shot stops".

In answer to the question posed by the OP?

Nope. Situations like this change nothing regarding how I select my retirement CCW choices.

Training (knowledge)
Skillset
Proper practice (skill maintenance)
Experience (ability to apply knowledge & skillset)
Mindset
Equipment (weapon/caliber/carry method)

I remember dealing with a good number of folks under the influence of PCP as a younger cop. Lots of training specific to dealing with people under the influence of it. I didn't have a choice whether I was carrying my .357 Magnum service revolver (125gr or 145gr JHP's), or later on my 9mm pistol (147gr JHP), or know whether I'd have time to have access to my patrol car's 12 gauge pump (buckshot/slugs) ... or whether I'd come upon an unexpected encounter while off-duty (armed with .38 Spl, .357 Mag, .45 ACP, 9mm, etc).

Regardless of what firearm I was equipped with while on & off-duty, though, I learned that it was my training, experience, skillset & mindset ... and being able to effectively utilize whatever equipment was at hand, as needed (or not) ... that was probably going to be critical.

I think some folks are perhaps susceptible to the Talisman Effect, knowingly or not, or may have unrealistic expectations for their defensive carry weapons.