Glock loaded, one in chamber, holstered on nightstand with a spare mag and surefire LX2.
We are having a baby in a few weeks - I will need to get a bedside safe in the next year I think. It will still be loaded with round chambered while in the safe.
**** gets too tricky when you are constantly clearing your gun when you come home every night - I like to leave all my guns with one in chamber and holstered. You have the least amount of ND risk the less you fiddle and there is no guess work if my guns are loaded - they always are.