Originally Posted by kirbinster
Wingryder, yes .22LR can be used by some semi handguns. I have a Kimber conversion slide for my 1911 that let's me fire .22 rather than the normal .45 cal.
He isn't asking about .22lr (long rifle), he is asking about .22 long. Different bullet, and no, probably won't work in a semi-auto pistol. It may feed ok, but typically the .22 long won't cycle a semi auto.
This pic shows the difference between .22 short, .22 long, and .22lr.