Wingryder, yes .22LR can be used by some semi handguns. I have a Kimber conversion slide for my 1911 that let's me fire .22 rather than the normal .45 cal.
I don't get why .22 is in such short supply, its not used by DHS or other government agencies. And almost no one uses it for concealed carry or home defense. Behind it is 9mm which is probably the second hardest size to find.
At my range things have gotten so bad that these are the current ammo policies:
Members may buy only 2 boxes of ammunition per day - excluding 9mm (limited to 1 box)
* Non-members may only purchase ammunition if renting a port and a firearm and are limited to 2 boxes
* No walk in sales right now