Know your backstop. Best case scenario is to shoot at targets lower than bore height with a good backstop (dirt mound) as tall as possible. I was shooting at plates yesterday from 75-100 yards. 165 gr. 40's @ 1150 muzzle took about 1 second to hit. The 165 gr. 10mm @ 1400 took about 3/4 second. I had'nt shot plates at that distance in a while and was surprised how much the bullets slowed down in that distance.
As was mentioned above, angle of the barrel has most to do with how far any given bullet will travel.