I carry a P220 Elite Stainless with an attached Viridian X5L a few days per month when I am wearing an over garment. A good gun belt makes the weight doable.
I have a P226 TacOps in 9mm but have never carried it.
I have read a few good reviews of the new P224 in .40 S&W during the last week or so now that they are starting to trickle out into stores. My wife wants to look into the P224 and I am somewhat interested though I do love my edc Glock 27.