Originally Posted by unit1069
Sorry for the confusion but my question doesn't pertain to reloading but only to overall range and effectiveness in multiple scenarios.
Pick which caliber you'd want to have as the sole choice.
It's an apples to airplanes comparison. The .44 Special is loaded weak intentionally by factories as there are many old handguns extant.
What scenario? Shooting bad guys? Hunting buffalo? Your question is too broad. However, if you don't reload you'll go broke shooting factory .44 Special. I have both calibers and reload.