I'm not big on service calibers for any large game animal. Consider they are marhginal for stopping a 200# man, It's not agood choice for those that take hunting seriously. If you want a 25yd handgun shot, start toting a 41 or 44mag.
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".