Originally Posted by unit1069
OP, if you don't yet know your preferences or particular caliber capabilities I suggest you take your time and investigate all the options.
This ^^is probably the best advice of all.
Also, on a more fundamental note, I believe someone suggested earlier that a wheel gun is good for developing handgun skills. Thats how many of us started, and it is a sensible place to begin.
English mentioned .22 as an option, and that's worth thinking about too. The ammo is so cheap, and you will probably want a .22 no matter how many larger caliber guns you acquire along the way.