I have 2 full size Glocks. The 17 and the 21 I would hate like the Devil to have to choose one and let the other one go. I have relatively small hands so initially the 17 felt more comfortable. I bought them just a few days apart in Jan of '06 and the 21 was a bit of a streetch but I was determined to adjust and I did. It didn't take as long as I thought it would and now it "fits" just fine. I have about 7K rounds through the 17 and exactly 3k through the 21 and I can shoot one just as well as the other and they are now equal in comfort to me. When I shoot the 21 these days I don't even think about that any more.
I know I'd love the 22 and the 20 just as well. Hopefully....some day....
G-17, G-23, G-21, G-36, Ruger blackhawk, ss, Ruger 10/22, Ruger Mark II, Ruger SP101, British Webley MKI .455, Kel-Tec P32, S&W top break .38, S&W 24-3 .44spl N frame Colt 1903 .32, Heritage .22 Combo, Colt AR-15, LE6920.