Unique is a good choice for 180gr bullets in the 40. Run it above midrange & it's not dirty. Sure there are other pwoders, like WSF, that are cleaner, but Uniue will run fine. TG, not if it were free. I'ld sell it to a noob & buy some WSF or WST.
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".