Originally Posted by Simplejack
Well you can't really predict any situation you might be in and you probably will never have to use your gun in your life time for self defense. So picking out a ammo that might be good for one situation might not be as good for another.
I just loaded up with some Hornady Critical Defense FTX bullets and I think that will be a good choice for most situation you might come across.
Or you can just carry 4 clips with different rounds in each and then you will have options depending on your situation, just be sure to label your mags
If you do have to shoot someone, you have to use your own best judgement to determine if it is safe to shoot in that direction, no ammo is going to solve that issue.
Hornaday Critical Defense FTX here as well.