I don't think you'll have any problem doing that.
The biggest problem is, as RWBlue said, there is little published reloading data. Hodgdon only lists up to 20,000 Cup. Not very helpfull when +P is 23,000 Cup, and I've been told Ace Custom who developed the round is loading at 27,000 Cup. There is no published maximum.
One thing that could help would be a 6 inch after market barrel - that would give slower powders a bit more time to act, which is supposed to help with heavier bullets.
It would be nice to have a reloading thread for 45 Super, similar to the threads on the 10mm Reloading forum.