I imagine shot placement isn't so critical when punching .45+" holes in nutria!
Gotta love the extended barrels they use, which make all the difference in .45 ballistics. I have a 6.6" SS LWD barrel and a #24 spring that I put in one of my G21SF's when I head out into bear country. Those 255 gr. Buffalo Bore hard-cast lead flatnoses don't slow down for much.