You can save about $40/K shooting lead. So if you shoot 3K rounds, you'll pay for the LW bbl. Some will even tell you to go ahead & just run lead thru the stock bbl. It can be done eaily enough in the 45acp, just clean it frequently.
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".