I've shot a lot of 230grn.RNs (plain lead, plated, jacketed) with 4.5grn. WST. A nice, soft, accurate load that runs well in all .45ACP pistols.
However, my everyday go-to, everything handload consists of a 200grn.LSWC w/5.0grns. WST. Superbly accurate, clean burning, easy recoiling and powerful it's only drawback is the SWC design which doesn't feed well in a lot of modern pistol designs (Glock, XD, etc.). For those I've subbed LRNFP (aka cowboy) bullets for just about the same results, slightly less accuracy.