I have a G22 and a G27. I prefer Hornady Critical Defense 165gr and or Ranger SXT-T Series 165gr. Both are very wicked SD rounds. Federal HST's are a good choice too.
G17 G19 G21SF G22 G27 G30 (All Gen 3's)
NAA & Davis 22 Magnum Derringers
Ruger 10/22 Custom Stainless